Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses.

@article{Yoon2014DifferentialRO,
  title={Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses.},
  author={Haejin Yoon and Seung-Hyun Shin and Dong Hoon Shin and Y. B. Chun and Jong-Wan Park},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={444 1},
  pages={36-43}
}
Hypoxia-inducible factors 1α and 2α (HIF-1α and HIF-2α) determine cancer cell fate under hypoxia. Despite the similarities of their structures, HIF-1α and HIF-2α have distinct roles in cancer growth under hypoxia, that is, HIF-1α induces growth arrest whereas HIF-2α promotes cell growth. Recently, sirtuin 1 (Sirt1) was reported to fine-tune cellular responses to hypoxia by deacetylating HIF-1α and HIF-2α. Yet, the roles of Sirt1 in HIF-1α and HIF-2α functions have been controversial. We here… CONTINUE READING

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