Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

  title={Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.},
  author={Guiscard Seebohm and Nathalie Strutz-Seebohm and Oana N. Ureche and Ravshan Baltaev and Angelika Lampert and Ganna Kornichuk and Kaichiro Kamiya and Thomas V. Wuttke and Holger Lerche and Michael C Sanguinetti and Florian Lang},
  journal={Biophysical journal},
  volume={90 6},
Voltage-gated K+ channel activation is proposed to result from simultaneous bending of all S6 segments away from the central axis, enlarging the aperture of the pore sufficiently to permit diffusion of K+ into the water-filled central cavity. The hinge position for the bending motion of each S6 segment is proposed to be a Gly residue and/or a Pro-Val-Pro motif in Kv1-Kv4 channels. The KCNQ1 (Kv7.1) channel has Ala-336 in the Gly-hinge position and Pro-Ala-Gly. Here we show that mutation of Ala… CONTINUE READING
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