Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

  title={Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses},
  author={Hiroki Kato and Osamu Takeuchi and Shintaro Sato and M. Yoneyama and Masahiro Yamamoto and Kosuke Matsui and Satoshi Uematsu and Andreas Jung and Taro Kawai and Ken J Ishii and Osamu Yamaguchi and Kinya Otsu and Tohru Tsujimura and Chang-sung Koh and Caetano Reis e Sousa and Yoshiharu Matsuura and Takashi Fujita and Shizuo Akira},
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA) and triggers antiviral responses. The cytoplasmic helicase proteins RIG-I (retinoic-acid-inducible protein I, also known as Ddx58) and MDA5 (melanoma-differentiation-associated gene 5, also known as Ifih1 or Helicard) have been implicated in viral dsRNA recognition. In vitro studies suggest that both RIG-I and MDA5 detect RNA viruses and polyinosine-polycytidylic acid… CONTINUE READING
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  • H Kato
  • Immunity 23,
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