Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation.

@article{Liu1999DifferentialRO,
  title={Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation.},
  author={Juan Liu and Kohji Fukunaga and Hideki Yamamoto and Katsuhide Nishi and Eishichi Miyamoto},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 19},
  pages={
          8292-9
        }
}
The roles of Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase II) and mitogen-activated protein kinase (MAPK) in long-term potentiation (LTP) were investigated in the CA1 area of hippocampal slices, using electrophysiological and biochemical approaches. A brief high-frequency stimulation, but not low-frequency stimulation, delivered to Schaffer collateral/commissural afferents produced a stable LTP and activated both CaM kinase II and 42 kDa MAPK. Different from the activity of CaM… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 58 references

Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1996
View 4 Excerpts
Highly Influenced

Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 4 Excerpts
Highly Influenced

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