Differential roles of CCL2 and CCR2 in host defense to coronavirus infection.

@article{Held2004DifferentialRO,
  title={Differential roles of CCL2 and CCR2 in host defense to coronavirus infection.},
  author={Katherine S. Held and Benjamin PC. Chen and William A. Kuziel and Barrett J. Rollins and Thomas E Lane},
  journal={Virology},
  year={2004},
  volume={329 2},
  pages={251-60}
}
The CC chemokine ligand 2 (CCL2, monocyte chemoattractant protein-1) is important in coordinating the immune response following microbial infection by regulating T cell polarization as well as leukocyte migration and accumulation within infected tissues. The present study examines the consequences of mouse hepatitis virus (MHV) infection in mice lacking CCL2 (CCL2(-/-)) in order to determine if signaling by this chemokine is relevant in host defense. Intracerebral infection of CCL2(-/-) mice… CONTINUE READING
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