Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea.

@article{Matsubara1991DifferentialRF,
  title={Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea.},
  author={Masayuki Matsubara and M T Girard and Claire Larkin Kublin and Charles Cintron and Maria E Fini},
  journal={Developmental biology},
  year={1991},
  volume={147 2},
  pages={425-39}
}
We have documented changes in collagenolytic/gelatinolytic enzymes of the matrix metalloproteinase family (MMP) in remodelling rabbit cornea. MMP-2 (65 kDa gelatinase) in the proenzyme form is synthesized by the cells of the normal corneal stroma. After keratectomy the level of MMP-2 is increased in the stroma and enzyme appears in both pro- and activated forms. In addition, corneal cells synthesize MMP-9 (92 kDa gelatinase) in the proenzyme form after keratectomy; expression occurs in both the… CONTINUE READING

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