Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.

@article{McNulty2012DifferentialRF,
  title={Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.},
  author={Susan E. McNulty and Ruth M. Barrett and Annie Vogel-Ciernia and Melissa Malvaez and Nicole Hernandez and M. Felicia Davatolhagh and Dina P Matheos and Aaron J Schiffman and Marcelo Wood},
  journal={Learning & memory},
  year={2012},
  volume={19 12},
  pages={588-92}
}
Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either Nr4a1 or Nr4a2, we found that Nr4a2 is necessary for both long-term memory for object location and object recognition. In contrast, Nr4a1 appears to be necessary only for object location. Indeed, their roles in these different… CONTINUE READING

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