Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function.

@article{Nagata2007DifferentialRO,
  title={Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function.},
  author={Yuko Nagata and Hajime Kamijuku and M Taniguchi and Steven F. Ziegler and Ken-ichiro Seino},
  journal={International archives of allergy and immunology},
  year={2007},
  volume={144 4},
  pages={305-14}
}
Asthma is an inflammatory lung disease, in which CD1d-restricted natural killer T (NKT) cells play an important pathogenic role. Also, recent reports indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma. Here we examined the relationship between NKT cells and TSLP in a mouse model of asthma. NKT cells express TSLP receptor as well as IL-7 receptor alpha-chain. TSLP acts on NKT cells to preferentially increase their IL-13… CONTINUE READING
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