Differential role of serotonergic polymorphisms in alcohol and heroin dependence
@article{Siz2009DifferentialRO, title={Differential role of serotonergic polymorphisms in alcohol and heroin dependence}, author={Pilar A. S{\'a}iz and Mar{\'i}a Paz Garc{\'i}a-Portilla and Gerardo Fl{\'o}rez and Celso Arango and Paul Corcoran and Blanca Morales and Mar{\'i}a Teresa Bobes Bascar{\'a}n and Cesar Alvarez and Gema San Narciso and Eduardo Carre{\~n}o and Victoria {\'A}lvarez and Eliecer Coto and Julio Bobes}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={2009}, volume={33}, pages={695-700} }
45 Citations
TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence
- Biology, MedicineEuropean Addiction Research
- 2016
The data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction, and replications of the findings are still needed.
Evaluation of the Association of Htr2a Gene Rs6313 Polymorphism with Heroin Dependence in a Sample from Northwest Iran
- Biologyjournal of ilam university of medical sciences
- 2021
The results of the study could not support a significant association between HTR2A rs6313 polymorphism and heroin dependence in the Azeri population of Northwest Iran, indicating the need to investigate other candidate genetic polymorphisms in the study population.
Characterization of serotonin transporter gene (SLC6A4) polymorphisms and its association with drug dependence in a Jordanian Arab population
- BiologyToxicology and industrial health
- 2014
A putative role of the 5-HTTLPR for drug dependence in the Jordanian Nationals of Arab ancestry is suggested.
Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
- BiologyNeuropsychiatric disease and treatment
- 2016
The results suggest an ethnic-specific effect of the 5-httlpr polymorphism on the risk for heroin dependence, but the influence of the genetic variance in the patients with comorbidities or intermediate phenotypes of heroin dependence needs to be further examined.
Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder
- Biology, PsychologyNeuropsychopharmacology
- 2013
The meta-analysis supports that the association of the SLC6A4 gene with substance use disorder varies depending on substances with different risk allele frequencies in the multi-cultural populations.
Genetic Polymorphism in the Promoter Region of Serotonin Transporter: Implications for Ethanol Abuse in Children and Adolescents.
- MedicineJournal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent
- 2016
The influence of the 5-HTTLPR allelic variants in children and adolescent misuse of alcohol might be considered for clinical management, preventing long-term behavior problem.
Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse
- BiologySubstance abuse and rehabilitation
- 2012
Future research on 5-HT addiction genetics should adopt whole-genome sequencing technology, utilize large study samples, and collect data from multiple ethnic groups to build on the work already conducted with the aim of utilizing 5- HT genetics in SUD treatment settings.
Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence
- Psychology, BiologyGenes, brain, and behavior
- 2013
The data show additional evidence for the involvement of the serotoninergic system in the genetic susceptibility to cocaine dependence, and the association between cocaine dependence and HTR2A in both subgroups of patients.
Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner
- Biology, PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2012
Association between DRD2, 5-HTTLPR, and ALDH2 genes and specific personality traits in alcohol- and opiate-dependent patients
- Biology, PsychologyBehavioural Brain Research
- 2013
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Findings support a contribution of the 5-HT2A gene to susceptibility to heroin dependence, as well as a possible synergistic effect of 5- HT2A and5-HTT genes on susceptibility toHeroin dependence.
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