Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells.

@article{Kikuchi2003DifferentialRO,
  title={Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells.},
  author={Kazuhiro Kikuchi and Yoshiki Yanagawa and Kazuya Iwabuchi and Kazunori On{\'o}e},
  journal={Immunology letters},
  year={2003},
  volume={89 2-3},
  pages={149-54}
}
Using a murine spleen-derived dendritic cell (DC) line (BC1) CD40-mediated interleukin (IL)-12 production was analyzed and compared between immature and mature DC. BC1 cells, immature DC (iDC), were maturated by treatment with lipopolysaccharide (LPS) or tumor necrosis factor (TNF)-alpha. IL-12 production of LPS-treated DC (LPS/DC) was markedly enhanced by… CONTINUE READING