Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice.

@article{Shashidharamurthy2013DifferentialRO,
  title={Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice.},
  author={Rangaiah Shashidharamurthy and Deepa K. Machiah and Jesse D. Aitken and Kalyani Putty and Gayathri Srinivasan and Benoit Chassaing and Charles A Parkos and Periasamy Selvaraj and Matam Vijay-Kumar},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 4},
  pages={1064-73}
}
OBJECTIVE Lipocalin 2 (LCN-2) is an innate immune protein that is expressed by a variety of cells and is highly up-regulated during several pathologic conditions, including immune complex (IC)-mediated inflammatory/autoimmune disorders. However, the function of LCN-2 during IC-mediated inflammation is largely unknown. Therefore, this study was undertaken to investigate the role of LCN-2 in IC-mediated diseases. METHODS The up-regulation of LCN-2 was determined by enzyme-linked immunosorbent… CONTINUE READING