Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus.

@article{Leemans2002DifferentialRO,
  title={Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus.},
  author={Jaklien C. Leemans and Margriet J.B.M. Vervoordeldonk and Sandrine Florquin and Kok P. M. van Kessel and Tom van der Poll},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={165 10},
  pages={
          1445-50
        }
}
Lipoteichoic acids (LTA) and peptidoglycans (PepG) are major components of the cell walls of gram-positive bacteria that trigger inflammatory responses in vitro. To study the in vivo effects of LTA and PepG from Staphylococcus aureus in lungs and to determine the role of interleukin (IL)-6 herein, these compounds were intranasally administered to IL-6 gene deficient (IL-6(-/-)) and wild type (IL-6(+/+)) mice. In IL-6(+/+) mice, LTA and PepG induced acute pulmonary inflammation in a dose… CONTINUE READING

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