Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

  title={Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis},
  author={Catherine L. Kennedy and Meri Najdovska and Hazel Tye and Louise McLeod and Lihou Yu and Andrew Gregory Jarnicki and Prithi S. Bhathal and Tracy L. Putoczki and Matthias Ernst and Brendan J Jenkins},
Signalling by the toll-like receptor (TLR) family of pathogen recognition receptors has emerged as a key molecular component in the pathogenesis of an increasing number of inflammatory-related cancers, among which gastric cancer rates as the second most lethal cancer world-wide. The myeloid differentiation factor 88 (MyD88) adapter molecule has a critical role in mediating innate immune signalling by members of the TLR and interleukin (IL)-1 families, and has been associated with either pro- or… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

Toll-like receptor

  • K Uno, K Kato, T Atsumi, T Suzuki, J Yoshitake, H Morita
  • of tumor inflammation. Cancer Cell
  • 2012

Tumor development in murine ulcerative colitis depends on MyD 88 signaling of colonic F 4 / 80 þ CD 11 b ( high ) Gr 1 ( low ) macrophages

  • G Schiechl, B Bauer, I Fuss, SA Lang, C Moser, P Ruemmele
  • J Clin Invest
  • 2011

Similar Papers

Loading similar papers…