Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

@article{Kennedy2014DifferentialRO,
  title={Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis},
  author={Catherine L. Kennedy and Meri Najdovska and Hazel Tye and Louise McLeod and Lihou Yu and Andrew Gregory Jarnicki and Prithi S. Bhathal and Tracy L. Putoczki and Matthias Ernst and Brendan J Jenkins},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={2540-2546}
}
Signalling by the toll-like receptor (TLR) family of pathogen recognition receptors has emerged as a key molecular component in the pathogenesis of an increasing number of inflammatory-related cancers, among which gastric cancer rates as the second most lethal cancer world-wide. The myeloid differentiation factor 88 (MyD88) adapter molecule has a critical role in mediating innate immune signalling by members of the TLR and interleukin (IL)-1 families, and has been associated with either pro- or… CONTINUE READING
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