Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.

@article{Messal2011DifferentialRF,
  title={Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.},
  author={Nassima Messal and {\'E}milie Mamessier and Aude Sylvain and Javier Celis-Gutierrez and Marie-Laure Thibult and Bruno Chetaille and Guyl{\`e}ne Firaguay and Sonia Pastor and Yves Claude Guillaume and Qian Wang and Ivan Hirsch and Jacques A Nun{\`e}s and Daniel Olive},
  journal={European journal of immunology},
  year={2011},
  volume={41 12},
  pages={
          3443-54
        }
}
The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engaged. These CD277-induced additive functional effects are in accordance with the detection of early T-cell activation events such as TCR-induced cell signaling being increased upon… CONTINUE READING
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