Differential role for CBP and p300 CREB-binding domain in motor skill learning.

@article{Oliveira2006DifferentialRF,
  title={Differential role for CBP and p300 CREB-binding domain in motor skill learning.},
  author={Ana M M Oliveira and Ted Abel and Paul K. Brindle and Marcelo Wood},
  journal={Behavioral neuroscience},
  year={2006},
  volume={120 3},
  pages={724-9}
}
Cyclic adenosine monophosphate response element binding protein (CREB) binding protein (CBP) and E1A binding protein (p300) are highly homologous transcriptional coactivators with histone acetyltransferase activity. Although CBP and p300 have unique functions in vivo during embryogenesis and hematopoiesis, their functions within the nervous system remain poorly understood. The authors demonstrate that these coactivators have differential roles in motor skill learning. Mice with a mutation in… CONTINUE READING
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