Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.

@article{Stern1986DifferentialRO,
  title={Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.},
  author={David F. Stern and Anita B. Roberts and Nanette S. Roche and Michael B. Sporn and Robert A Weinberg},
  journal={Molecular and cellular biology},
  year={1986},
  volume={6 3},
  pages={870-7}
}
To identify functional relationships between oncogenes and growth factors, we compared the effects of transfected myc and ras oncogenes on the responsiveness of Fischer rat 3T3 cells to three growth factors: epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and transforming growth factor-beta (TGF-beta). Control cells did not grow in soft agar under any conditions. ras-Transfected cells grew in soft agar under all conditions tested and were insensitive to the stimulatory… CONTINUE READING