Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry

@article{Sahn2006DifferentialRT,
  title={Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry},
  author={Ignasi Sah{\'u}n and Xavier Gallego and M{\'o}nica Gratac{\'o}s and Patricia Murtra and Ramon Trullas and Rafael Maldonado and Xavier Estivill and Mara Dierssen},
  journal={Amino Acids},
  year={2006},
  volume={33},
  pages={677-688}
}
Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellularity in brain regions, such as the locus ceruleus, that are important neural substrates for the expression of anxiety in severe anxiety states. Here, we investigated the sensitivity… CONTINUE READING