Differential responses of tumors and normal brain to the combined treatment of 2-DG and radiation in glioablastoma.

@article{Prasanna2009DifferentialRO,
  title={Differential responses of tumors and normal brain to the combined treatment of 2-DG and radiation in glioablastoma.},
  author={Venkatesh K Prasanna and Neelam Krishnan Venkataramana and Bilikere Srinivasa Rao Dwarakanath and V. R. Santhosh},
  journal={Journal of cancer research and therapeutics},
  year={2009},
  volume={5 Suppl 1},
  pages={S44-7}
}
2-Deoxy-D-glucose (2-DG), an inhibitor of glucose transport and glycolysis, enhances radiation damage selectively in tumor cells by modulating damage response pathways resulting in cell death in vitro and local tumor control. Phase I and II clinical trials in patients with malignant glioma have shown excellent tolerance to a combined treatment of orally… CONTINUE READING