Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.

@article{Bali2012DifferentialRO,
  title={Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.},
  author={Namrata Bali and Jason M Arimoto and Nahoko Iwata and Sharon W Lin and Liqin Zhao and Roberta Diaz Brinton and Todd E Morgan and Caleb E. Finch},
  journal={Endocrinology},
  year={2012},
  volume={153 2},
  pages={759-69}
}
Progesterone (P4) and estradiol (E2) modulate neurogenesis and synaptic remodeling in the hippocampus during the rat estrous cycle and in response to deafferenting lesions, but little is known about the steroidal regulation of hippocampal progesterone receptors associated with these processes. We examined the neuronal expression of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr), by in situ hybridization and immunohistochemistry. Pgr, a… CONTINUE READING

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