Differential responses of pancreatic β-cells to ROS and RNS.

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) direct the activation of distinct signaling pathways that determine cell fate. In this study, the pathways activated and the mechanisms by which ROS and RNS control the viability of pancreatic β-cells were examined. Although both nitric oxide and hydrogen peroxide (H₂O₂) induce DNA damage… (More)
DOI: 10.1152/ajpendo.00424.2012

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