Differential responses of hypothalamus-pituitary-adrenal axis immediate early genes to corticosterone and circadian drive.

@article{Girotti2007DifferentialRO,
  title={Differential responses of hypothalamus-pituitary-adrenal axis immediate early genes to corticosterone and circadian drive.},
  author={Milena Girotti and Marc S Weinberg and Robert L Spencer},
  journal={Endocrinology},
  year={2007},
  volume={148 5},
  pages={2542-52}
}
The hypothalamus-pituitary-adrenal (HPA) axis diurnal cycle of activity is manifest in circadian rhythms of ACTH and corticosterone secretion, which in the rat peak around the onset of the dark period. This cycle is thought to be driven by daily fluctuations in activity of CRH neurons within the paraventricular nucleus of the hypothalamus (PVN), controlled by suprachiasmatic nucleus inputs. In this study we examined whether the circadian drive that regulates ACTH and corticosterone basal… CONTINUE READING

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