Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial.

@article{Freeman1999DifferentialRT,
  title={Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial.},
  author={Ellen W. Freeman and Karl E. Rickels and Steven J. Sondheimer and Marilyn M. Polansky},
  journal={Archives of general psychiatry},
  year={1999},
  volume={56 10},
  pages={
          932-9
        }
}
BACKGROUND Studies show that selective serotonin reuptake inhibitors are effective for severe premenstrual syndrome and premenstrual dysphoric disorder. This study compares the efficacy of a selective serotonin reuptake inhibitor with that of a tricyclic antidepressant to determine whether efficacy for premenstrual syndrome/premenstrual dysphoric disorder is a general or more serotonergic effect of antidepressants. METHODS After 3 screening months, 189 subjects were randomized to sertraline… Expand
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Diagnosis and treatment of premenstrual dysphoric disorder.
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TLDR
Fluoxetine was significantly superior to bupropion and placebo as an effective treatment for PMDD, and patient satisfaction was far greater with fluoxettine. Expand
Sertraline versus desipramine in the treatment of premenstrual syndrome: an open-label trial.
TLDR
Sertraline and possibly desipramine appear to be effective treatments for PMS, and sertralines was better tolerated, resulting in greater patient acceptance, and a placebo-controlled trial is clearly needed to support or refute these preliminary findings. Expand
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Serotonin reuptake inhibitors such as sertraline are useful therapeutic options for women with premenstrual dysphoria as reflected by symptomatic improvement and change in reported functional impairment. Expand
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TLDR
Luteal phase treatment with sertraline was a safe and effective treatment for moderate-to-severe premenstrual dysphoric disorder and a repeated-measures analysis of variance for crossover designs found a significant beneficial effect from sERTraline treatment in improving the calendar of pre menstrual experiences. Expand
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TLDR
Luteal phase treatment with sertraline was a safe and effective treatment for moderate-to-severe premenstrual dysphoric disorder and a repeated-measures analysis of variance for crossover designs found a significant beneficial effect from sERTraline treatment in improving the calendar of pre menstrual experiences. Expand
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TLDR
Fluoxetine's efficacy extended over a range of affective, physical and behavioural symptoms; its superiority obtained whether it preceded or followed placebo; and the relationship between steady-state drug level and clinical outcome was assessed. Expand
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TLDR
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TLDR
The study confirms the previously reported effectiveness of low doses of clomipramine in the treatment of premenstrual syndrome and demonstrates that the time lag between onset of medication and clinical effect is shorter when clomIPramine is used for premen menstrual syndrome than when it is use for depression, panic disorder, or obsessive compulsive disorder. Expand
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TLDR
It is concluded that low doses of clomipramine effectively reduce premenstrual irritability and dysphoria with a response rate close to 100%. Expand
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