Differential response to 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in non-small cell lung cancer cells with distinct oncogene mutations.

Abstract

We previously demonstrated that non-small cell lung cancer (NSCLC) cells and primary human lung tumors aberrantly express the vitamin D3-catabolizing enzyme, CYP24, and that CYP24 restricts transcriptional regulation and growth control by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in NSCLC cells. To ascertain the basis for CYP24 dysregulation, we assembled a… (More)
DOI: 10.1016/j.jsbmb.2012.09.022

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@article{Zhang2013DifferentialRT, title={Differential response to 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in non-small cell lung cancer cells with distinct oncogene mutations.}, author={Qiuhong Zhang and Beatriz Kanterewicz and Suzanne F. Shoemaker and Qiang Hu and Song Liu and Kristopher Atwood and Pamela A. Hershberger}, journal={The Journal of steroid biochemistry and molecular biology}, year={2013}, volume={136}, pages={264-70} }