Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer

  title={Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer},
  author={Allen M. Chen and Judy F-C Li and Laurel A Beckett and T. Zhara and Gregory Farwell and Derick H. M. Lau and Regina Frances Gandour-Edwards and Andrew T Vaughan and J. Purdy},
  journal={The Laryngoscope},
To evaluate the responsiveness of human papillomavirus (HPV) ‐positive and HPV‐negative oropharyngeal cancer to intensity‐modulated radiotherapy (IMRT), using axial imaging obtained daily during the course of image‐guided radiotherapy (IGRT). 

Nodal response after 46 Gy of intensity‐modulated radiotherapy is associated with human papillomavirus–related oropharyngeal carcinoma

This study aimed to analyze the effect of human papillomavirus (HPV)‐associated T1‐2 node‐positive oropharyngeal squamous cell carcinoma (OPSCC) on nodal response, recurrent disease, and survival in

Management of postradiation late hemorrhage following treatment for HPV‐positive oropharyngeal squamous cell carcinoma

Acute oropharyngeal hemorrhage is a serious complication for patients with oropharyngeal squamous cell carcinoma (OPSCC), particularly in patients with a history of radiation therapy (RT).

Role of primary surgery in the treatment of advanced oropharyngeal cancer

Patients with advanced stage oropharyngeal squamous cell carcinoma are compared according to surgical and nonsurgical treatments, when stratified by smoking and p16 status to compare survival outcomes.

The Contagious Head and Neck Cancer: The Role of Human PapillomavirusHPV

The role of HPV in the rise of HNSCC in women, with a focus on shifting clinical practice guidelines, is discussed.

Patient‐reported quality‐of‐life outcomes after de‐escalated chemoradiation for human papillomavirus‐positive oropharyngeal carcinoma: Findings from a phase 2 trial

The current study represents a subset analysis of quality‐of‐life (QOL) outcomes among patients treated on a phase 2 trial of de‐escalated chemoradiation for human papillomavirus (HPV)‐associated

The relationship between patterns of failure and human papilloma virus (HPV) status for squamous cell carcinoma of the oropharynx after definitive chemoradiotherapy: what role does elective nodal irradiation play?

HPV/p 16− patients have trends toward worse overall survival, locoregional recurrence, and distant metastasis, and lower elective nodal doses in HPV/p16− patients may increase the risk for elective neck failure.

Contemporary Opportunities in Nonsurgical Management of Locoregionally Advanced Head and Neck Squamous Cell Carcinoma

Evidence that loco-regional management can be de-intensified following a favorable response to induction treatment would provide an attractive option for HPV(+) OPSCC patients while also addressing risk of developing distant disease.

The rationale for HPV-related oropharyngeal cancer de-escalation treatment strategies

Truly HPV-related cancers (p16-positive and HPV DNA-positive with biomarkers for good response to therapy could be included in randomized trials aiming for less severe and better tailored therapy.

What is the best treatment for patients with human papillomavirus–positive and –negative oropharyngeal cancer?

Current and investigational treatment strategies in patients with both HPV‐positive and HPV‐negative oropharyngeal SCC are focused on, with particular interest in low‐risk patients.



Human papillomavirus positive squamous cell carcinoma of the oropharynx

The authors retrospectively determined the presence of the virus and the integrity of the viral E2 gene in tumors of patients who have undergone curative irradiation of patients with squamous cell carcinoma of the oropharynx.

Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus‐associated head and neck cancer based on a prospective clinical experience

Human papillomavirus is a causative agent in a subset of head and neck squamous cell carcinomas that have a clinicopathologic profile that diverges from HPV‐negative HNSCCs, and testing may soon become integrated into standard pathologic assessment of HNSccs.

Human papillomavirus and survival of patients with oropharyngeal cancer.

Tumor HPV status is a strong and independent prognostic factor for survival among patients with oropharyngeal cancer and the risk of death significantly increased with each additional pack-year of tobacco smoking.

Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.

For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.

Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer.

In vivo, HPV-positive tumors were more sensitive to radiation, with complete clearance at 20 Gy, compared with their HPV-negative counterparts, which showed persistent growth, and radiation and cisplatin induce an immune response to this antigenic cancer.

Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis

The observed improved OS and DFS for HPV‐positive HNSCC patients is specific to the oropharynx; these tumours may have a distinct etiology from those tumours in non‐oropharyngeal sites.

Human papilloma virus (HPV) DNA associated with prognosis of cervical cancer after radiotherapy.

Low initial human papilloma viral load implicates worse prognosis in patients with uterine cervical cancer treated with radiotherapy.

  • Joo-Young KimSohee Park S. Park
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2009
The data suggest that HPV viral load is a strong independent prognostic factor for DFS, and the prognostic model developed using the outcome data performed well in predicting the risk of relapse.

Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck.

PURPOSE A subset of head and neck cancers is associated with the human papillomavirus (HPV). Viral infection is closely correlated with expression of p16(INK4A) in these tumors. We evaluated

High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma.

  • L. LicitraF. Perrone S. Pilotti
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
The molecular and clinical results are in agreement with previous findings but provide additional information into the biologic mechanisms involved in HR-HPV oropharyngeal cancer in comparison to HPV-negative tumors.