Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer

@article{Chen2013DifferentialRR,
  title={Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer},
  author={Allen M. Chen and Judy F-C Li and Laurel A Beckett and T. Zhara and Gregory Farwell and Derick H. M. Lau and Regina Frances Gandour-Edwards and Andrew T Vaughan and J. Purdy},
  journal={The Laryngoscope},
  year={2013},
  volume={123}
}
To evaluate the responsiveness of human papillomavirus (HPV) ‐positive and HPV‐negative oropharyngeal cancer to intensity‐modulated radiotherapy (IMRT), using axial imaging obtained daily during the course of image‐guided radiotherapy (IGRT). 

Nodal response after 46 Gy of intensity‐modulated radiotherapy is associated with human papillomavirus–related oropharyngeal carcinoma

This study aimed to analyze the effect of human papillomavirus (HPV)‐associated T1‐2 node‐positive oropharyngeal squamous cell carcinoma (OPSCC) on nodal response, recurrent disease, and survival in

Management of postradiation late hemorrhage following treatment for HPV‐positive oropharyngeal squamous cell carcinoma

Acute oropharyngeal hemorrhage is a serious complication for patients with oropharyngeal squamous cell carcinoma (OPSCC), particularly in patients with a history of radiation therapy (RT).

Role of primary surgery in the treatment of advanced oropharyngeal cancer

Patients with advanced stage oropharyngeal squamous cell carcinoma are compared according to surgical and nonsurgical treatments, when stratified by smoking and p16 status to compare survival outcomes.

The Contagious Head and Neck Cancer: The Role of Human PapillomavirusHPV

The role of HPV in the rise of HNSCC in women, with a focus on shifting clinical practice guidelines, is discussed.

Patient‐reported quality‐of‐life outcomes after de‐escalated chemoradiation for human papillomavirus‐positive oropharyngeal carcinoma: Findings from a phase 2 trial

The current study represents a subset analysis of quality‐of‐life (QOL) outcomes among patients treated on a phase 2 trial of de‐escalated chemoradiation for human papillomavirus (HPV)‐associated

The relationship between patterns of failure and human papilloma virus (HPV) status for squamous cell carcinoma of the oropharynx after definitive chemoradiotherapy: what role does elective nodal irradiation play?

HPV/p 16− patients have trends toward worse overall survival, locoregional recurrence, and distant metastasis, and lower elective nodal doses in HPV/p16− patients may increase the risk for elective neck failure.

Contemporary Opportunities in Nonsurgical Management of Locoregionally Advanced Head and Neck Squamous Cell Carcinoma

Evidence that loco-regional management can be de-intensified following a favorable response to induction treatment would provide an attractive option for HPV(+) OPSCC patients while also addressing risk of developing distant disease.

The rationale for HPV-related oropharyngeal cancer de-escalation treatment strategies

Truly HPV-related cancers (p16-positive and HPV DNA-positive with biomarkers for good response to therapy could be included in randomized trials aiming for less severe and better tailored therapy.

What is the best treatment for patients with human papillomavirus–positive and –negative oropharyngeal cancer?

Current and investigational treatment strategies in patients with both HPV‐positive and HPV‐negative oropharyngeal SCC are focused on, with particular interest in low‐risk patients.

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The authors retrospectively determined the presence of the virus and the integrity of the viral E2 gene in tumors of patients who have undergone curative irradiation of patients with squamous cell carcinoma of the oropharynx.

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The data suggest that HPV viral load is a strong independent prognostic factor for DFS, and the prognostic model developed using the outcome data performed well in predicting the risk of relapse.

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The molecular and clinical results are in agreement with previous findings but provide additional information into the biologic mechanisms involved in HR-HPV oropharyngeal cancer in comparison to HPV-negative tumors.