Differential response of the murine IL-12 p35 gene to lipopolysaccharide compared with interferon-gamma and CD40 ligation.

@article{Vaidyanathan2001DifferentialRO,
  title={Differential response of the murine IL-12 p35 gene to lipopolysaccharide compared with interferon-gamma and CD40 ligation.},
  author={Hema Vaidyanathan and John D. Gentry and A Weatherman and Steven D. Schwartzbach and Thomas M. Petro},
  journal={Cytokine},
  year={2001},
  volume={16 1},
  pages={1-9}
}
Expression of the heterodimeric cytokine interleukin-(IL-)12 is induced by pattern recognition receptors responding to microbial stimuli such as lipopolysaccharide (LPS) and products of the immune system such as interferon-gamma (IFN-gamma) and CD40L. The formation of bioactive IL-12 requires equimolar synthesis of p35 and p40 subunits. However, p35 expression limits the amount of IL-12 formed. Transcription of the gene for the p35 subunit of IL-12 initiates within the first exon, an alternate… CONTINUE READING