Differential response of neurotensin to methamphetamine self-administration.

  title={Differential response of neurotensin to methamphetamine self-administration.},
  author={Paul S. Frankel and Amanda J. Hoonakker and Glen R. Hanson},
  journal={Annals of the New York Academy of Sciences},
Neurotensin (NT) is a tridecapeptide associated with extrapyramidal and limbic pathways and is thought to inhibit dopamine (DA) functions in nigrostriatal, mesocortical, and mesolimbic systems. Because of these effects, NT has been referred to as an endogenous neuroleptic. We previously reported that low, high, and multiple doses of psychostimulants such as methamphetamine (METH) have profound effects on tissue levels, expression of associated mRNA, and release of NT in DA-linked brain… CONTINUE READING

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