Differential response of miRNA-21 and its targets after traumatic brain injury in aging mice.


The present study investigated the possible role of miR-21, a miRNA that has known prosurvival function, in poor outcomes in the elderly following traumatic brain injury compared to adults. Controlled cortical impact injury was induced in adult (5-6 months) and aged (22-24 months) C57/BL6 mice. miR-21 and four of its targets (PDCD4, TIMP3, RECK, PTEN) were… (More)
DOI: 10.1016/j.neuint.2014.09.009


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