Commentary: The Expression of CD123 Can Decrease with Basophil Activation: Implications for the Gating Strategy of the Basophil Activation Test
- Salvatore Chirumbolo
- Front. Immunol.
- 2016
Highly Influenced
15 Excerpts
Differential response of human basophil activation markers: a multi-parameter flow cytometry approach
@article{Chirumbolo2008DifferentialRO,
title={Differential response of human basophil activation markers: a multi-parameter flow cytometry approach},
author={Salvatore Chirumbolo and Antonio Vella and Riccardo Ortolani and Marzia de Gironcoli and Pietro Solero and Giuseppe Tridente and Paolo Bellavite},
journal={Clinical and Molecular Allergy : CMA},
year={2008},
volume={6},
pages={12 - 12}
}- Published in Clinical and molecular allergy : CMA 2008
DOI:10.1186/1476-7961-6-12
BACKGROUND
Basophils are circulating cells involved in hypersensitivity reactions and allergy but many aspects of their activation, including the sensitivity to external triggering factors and the molecular aspects of cell responses, are still to be focused. In this context, polychromatic flow cytometry (PFC) is a proper tool to investigate basophil function, as it allows to distinguish the expression of several membrane markers upon activation in multiple experimental conditions.
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