Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species

@article{Mattiuzzo2007DifferentialRT,
  title={Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species},
  author={Giada Mattiuzzo and Magda Matouskova and Yasuhiro Takeuchi},
  journal={Retrovirology},
  year={2007},
  volume={4},
  pages={93 - 93}
}
The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses. A human-tropic PERV subgroup, PERV-A, can enter human cells through either of two homologous multitransmembrane proteins, huPAR-1 and huPAR-2. Here, we characterised human PARs and their homologues in the PERV-A resistant rodent species, mouse and rat (muPAR and… CONTINUE READING
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