Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.

@article{Park2013DifferentialRF,
  title={Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.},
  author={Chungoo Park and Xiaoshu Chen and Jian-Rong Yang and Jianzhi Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 8},
  pages={E678-86}
}
The cause of the tremendous among-protein variation in the rate of sequence evolution is a central subject of molecular evolution. Expression level has been identified as a leading determinant of this variation among genes encoded in the same genome, but the underlying mechanisms are not fully understood. We here propose and demonstrate that a requirement for stronger folding of more abundant mRNAs results in slower evolution of more highly expressed genes and proteins. Specifically, we show… CONTINUE READING
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RNA: Life’s Indispensable Molecule (Cold Spring Harbor Lab Press, Cold Spring Harbor, N.Y.), pp xiv

  • JE Darnell
  • 2011

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