Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus.

@article{Fuse2011DifferentialRF,
  title={Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus.},
  author={Shinichiro Fuse and Ching-Yi Daphne Tsai and Leah M Rommereim and Weijun Zhang and Edward J. Usherwood},
  journal={Cellular immunology},
  year={2011},
  volume={266 2},
  pages={130-4}
}
Vaccinia virus infection can confer immunity to smallpox by inducing potent T cell and antibody responses. While the CD8 T cell response to vaccinia virus has been well characterized, less is known about factors required for priming and memory for the CD4 T cells. Focusing on two recently described epitopes, we show that after intranasal infection, both I1L and L4R epitopes are co-dominant during the acute response, but the I1L epitope dominates during memory. CD4 T cell priming was intact in… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
8 Citations
10 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Eur

  • E. M. Bertram, A. Tafuri, +6 authors T. H. Watts
  • J. Immunol. 32 (12)
  • 2002
Highly Influential
6 Excerpts

Int

  • J. E. Christensen, J. P. Christensen, N. N. Kristensen, N. J. Hansen, A. Stryhn, A. R. Thomsen
  • Immunol. 14 (7)
  • 2002
Highly Influential
6 Excerpts

J

  • L. Garidou, S. Heydari, P. Truong, D. G. Brooks, D. B. McGavern
  • Virol. 83 (17)
  • 2009

Semin

  • A. C. Boesteanu, P. D. Katsikis
  • Immunol. 21 (2)
  • 2009
2 Excerpts

S

  • A. Sette, M. Moutaftsi, +12 authors P. L. Felgner
  • Crotty, Immunity 28 (6)
  • 2008
3 Excerpts

Microbes Infect

  • S. Wang, L. Chen
  • 6 (8)
  • 2004
1 Excerpt

Nat

  • C. Orabona, U. Grohmann, +9 authors P. Puccetti
  • Immunol. 5 (11)
  • 2004

A

  • I. M. Belyakov, P. Earl
  • Dzutsev, V.A. Kuznetsov, M. Lemon, L.S. Wyatt, J…
  • 2003
1 Excerpt

Annu

  • B. M. Carreno, M. Collins
  • Rev. Immunol. 20
  • 2002
1 Excerpt

Immunol

  • A. J. McAdam, A. N. Schweitzer, A. H. Sharpe
  • Rev. 165
  • 1998
1 Excerpt

Similar Papers

Loading similar papers…