Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells.

@article{Marra2004DifferentialRO,
  title={Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells.},
  author={Fabio Marra and Wanda Delogu and Ilaria Petrai and Sabrina Pastacaldi and Andrea Bonacchi and Eva Efsen and Sara Aleffi and Cristiana Bertolani and Massimo Pinzani and Paolo Gentilini},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={287 1},
  pages={G18-26}
}
Hepatic stellate cells (HSC) coordinate the liver wound-healing response through secretion of several cytokines and chemokines, including CCL2 (formerly known as monocyte chemoattractant protein-1). In this study, we evaluated the role of different proteins of the MAPK family (ERK, p38(MAPK), and JNK) in the regulation of CCL2 expression by HSC, as an index of their proinflammatory activity. Several mediators activated all three MAPK, including TNF, IL-1, and PDGF. To assess the relative role… CONTINUE READING

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