Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

Abstract

Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membrane regulating cell–cell adhesion… (More)
DOI: 10.1038/ncb2260

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