Differential requirement for centriolar satellites in cilium formation among different vertebrate cells

@inproceedings{Odabasi2018DifferentialRF,
  title={Differential requirement for centriolar satellites in cilium formation among different vertebrate cells},
  author={Ezgi Odabasi and Signe K Ohlsen and Seref Gul and Halil Kavakli and Jens S. Andersen and Elif Nur Firat-Karalar},
  year={2018}
}
Centriolar satellites are ubiquitous in vertebrate cells. They have recently emerged as key regulators of centrosome/cilium biogenesis, and their mutations are linked to ciliopathies. However, their precise functions and mechanisms of action, which potentially differ between cell types, remain poorly understood. Here, we generated retinal pigmental and kidney epithelial cells lacking satellites by genetically ablating PCM1 to investigate their functions. While satellites were essential for… CONTINUE READING