Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease.

@article{Puliaev2004DifferentialRF,
  title={Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease.},
  author={Roman Puliaev and Phuong X Nguyen and Fred D. Finkelman and Charles S. Via},
  journal={Journal of immunology},
  year={2004},
  volume={173 2},
  pages={910-9}
}
Although IFN-gamma is the archetypal Th1 cytokine, its role in CTL maturation is uncertain. We used an in vivo mouse model of CTL development, parent-into-F(1) acute graft-vs-host disease (AGVHD), to evaluate this issue. In AGVHD, transfer of naive parental T cells into F(1) hosts stimulates the development of allospecific CTL effectors that eliminate host lymphocytes, particularly B cells. Complete elimination of IFN-gamma, using IFN-gamma-deficient donors and administering anti-IFN-gamma mAb… CONTINUE READING

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