Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.

@article{Rogaeva2007DifferentialRB,
  title={Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.},
  author={Anastasia Rogaeva and X M Ou and Hamed Jafar-Nejad and Sylvie Lemonde and Paul R Albert},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 29},
  pages={20897-905}
}
Freud-1/CC2D1A is a transcriptional repressor of the serotonin-1A receptor gene and was recently genetically linked to non-syndromic mental retardation. To identify new Freud-1 gene targets, data base mining for Freud-1 recognition sequences was done. A highly homologous intronic element (D2-DRE) was identified in the human dopamine-D2 receptor (DRD2) gene, and the role of Freud-1 in regulating the gene at this site was assessed. Recombinant Freud-1 bound specifically to the D2-DRE, and a major… CONTINUE READING

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