Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes.

@article{Hussmann2013DifferentialRO,
  title={Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes.},
  author={Katherine L. Hussmann and Melanie A. Samuel and Kwang Sik Kim and Michael S Diamond and Brenda L. Fredericksen},
  journal={Journal of virology},
  year={2013},
  volume={87 5},
  pages={2814-22}
}
The severity of West Nile virus (WNV) infection in immunocompetent animals is highly strain dependent, ranging from avirulent to highly neuropathogenic. Here, we investigate the nature of this strain-specific restriction by analyzing the replication of avirulent (WNV-MAD78) and highly virulent (WNV-NY) strains in neurons, astrocytes, and microvascular endothelial cells, which comprise the neurovascular unit within the central nervous system (CNS). We demonstrate that WNV-MAD78 replicated in and… CONTINUE READING
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