Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.

@article{Seubert2005DifferentialRG,
  title={Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.},
  author={John M. Seubert and Fang Xu and Joan P. Graves and Jennifer Brady Collins and Stella Sieber and Richard S. Paules and Deanna L. Kroetz and Darryl C. Zeldin},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 3},
  pages={F552-61}
}
Development of hypertension stems from both environmental and genetic factors wherein the kidney plays a central role. Spontaneously hypertensive rats (SHR) and the nonhypertensive Wistar-Kyoto (WKY) controls are widely used as a model for studying hypertension. The present study examined the renal gene expression profiles between SHR and WKY at a prehypertensive stage (3 wk of age) and hypertensive stage (9 wk of age). Additionally, age-related changes in gene expression patterns were examined… CONTINUE READING

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