Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter.

@article{Jaber1999DifferentialRO,
  title={Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter.},
  author={Mohamed Jaber and Brigitte Dumartin and Corinne Sagn{\'e} and John W Haycock and Christine Roubert and Bruno Giros and Bertrand Bloch and Marc G. Caron},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 10},
  pages={3499-511}
}
Mice lacking the dopamine transporter (DAT) display biochemical and behavioural dopaminergic hyperactivity despite dramatic alteration in dopamine homeostasis. In order to determine the anatomical and functional integrity of the dopaminergic system, we examined the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis as well as DOPA decarboxylase and vesicular monoamine transporter. TH-positive neurons in the substantia nigra were only slightly decreased (-27… CONTINUE READING

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