Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation.

@article{Docagne2005DifferentialRO,
  title={Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation.},
  author={Fabian Docagne and Sandra J. Campbell and Adrian F. Bristow and Stephen Poole and Stephan Vigues and Carmen Guaza and V Hugh Perry and Daniel C. Anthony},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 5},
  pages={1205-14}
}
Most pathologies of the brain have an inflammatory component, associated with the release of cytokines such as interleukin-1beta (IL-1beta) from resident and infiltrating cells. The IL-1 type I receptor (IL-1RI) initiates a signalling cascade but the type II receptor (IL-1RII) acts as a decoy receptor. Here we have investigated the expression of IL-1beta… CONTINUE READING