Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.

@article{Go1995DifferentialRO,
  title={Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.},
  author={L O Go and Maria C. Moschella and James Watras and Kumud Kumar Handa and Billie S Fyfe and Andrew Robert Marks},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 2},
  pages={888-94}
}
The molecular basis of human heart failure is unknown. Alterations in calcium homeostasis have been observed in failing human heart muscles. Intracellular calcium-release channels regulate the calcium flux required for muscle contraction. Two forms of intracellular calcium-release channels are expressed in the heart: the ryanodine receptor (RyR) and the inositol 1,4,5-trisphosphate receptor (IP3R). In the present study we showed that these two cardiac intracellular calcium release channels were… CONTINUE READING

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