Differential regulation of transendothelial migration of THP-1 cells by ICAM-1/LFA-1 and VCAM-1/VLA-4.

@article{Ronald2001DifferentialRO,
  title={Differential regulation of transendothelial migration of THP-1 cells by ICAM-1/LFA-1 and VCAM-1/VLA-4.},
  author={John Anton Chrisostom Ronald and Carmen V. Ionescu and Kem A. Rogers and Martin Sandig},
  journal={Journal of leukocyte biology},
  year={2001},
  volume={70 4},
  pages={601-9}
}
The adhesion molecules intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expressed in atherogenic lesions are thought to regulate monocyte diapedesis. To better understand their specific roles we used function-blocking antibodies and examined in a culture model the morphology, motility, and diapedesis of THP-1 cells interacting with human coronary artery endothelial cells. The number of motile THP-1 cells was reduced only when VCAM-1 or both ICAM-1 and… CONTINUE READING
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