Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice.


OBJECTIVE We hypothesized that downregulation of the antioxidant thioredoxin system contributes to oxidative stress in angiotensin II-induced hypertension. As oestrogen may protect against oxidative stress, we also evaluated whether the thioredoxin system, particularly in the heart, is differentially regulated between females and males. RESULTS C57Bl/6… (More)


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