Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA.

@article{Jitrapakdee2007DifferentialRO,
  title={Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA.},
  author={Sarawut Jitrapakdee and A Adina-zada and Paul G. Besant and Kathy H Surinya and Wm. Cleland and J. C. Wallace and Paul V. Attwood},
  journal={The international journal of biochemistry & cell biology},
  year={2007},
  volume={39 6},
  pages={
          1211-23
        }
}
Unlike other eukaryotes studied to date, yeast has two genes for pyruvate carboxylase coding for very similar, but not identical, isozymes (Pyc1 and Pyc2), both of which are located in the cytoplasm. We have found that there are marked differences in the kinetic properties of the isozymes potentially leading to differential regulation of Pyc1 and Pyc2 activity by both activators and substrates. For example, Pyc2 is only activated 3.7-fold by acetyl CoA, and 9.6-fold by NH(4)(+), whilst the… CONTINUE READING
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