Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

@article{Papadimitriou2012DifferentialRO,
  title={Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition},
  author={Elsa Papadimitriou and Eleftheria Vasilaki and Christina Vorvis and Dimitrios C. Iliopoulos and Aristidis Moustakas and Dimitris Kardassis and Christos Stournaras},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={2862-2875}
}
In the present study we analyzed the regulation of the two isoforms of the RhoA-specific guanine nucleotide exchange factor Net1 by transforming growth factor-β (TGF-β) in keratinocytes. We report that short-term TGF-β treatment selectively induced Net1 isoform2 (Net1A) but not Net1 isoform1. This led to upregulation of cytoplasmic Net1A protein levels that were necessary for TGF-β-mediated RhoA activation. Smad signaling and the MAPK/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK… CONTINUE READING
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