Differential regulation of the transforming growth factor type-beta 2 gene promoter in embryonal carcinoma cells and their differentiated cells.

@article{Kelly1992DifferentialRO,
  title={Differential regulation of the transforming growth factor type-beta 2 gene promoter in embryonal carcinoma cells and their differentiated cells.},
  author={David L. Kelly and Michael A O'reilly and Angie Rizzino},
  journal={Developmental biology},
  year={1992},
  volume={153 1},
  pages={172-5}
}
Previous studies have shown that EC cells do not express detectable levels of TGF-beta 2 or its mRNA until they differentiate. This suggested that differentiation influences the transcription of the TGF-beta 2 gene in this model system. To address this possibility, we have examined the activity of the TGF-beta 2 promoter in EC cells and their differentiated cells using gene constructs containing various portions of the TGF-beta 2 promoter inserted upstream of the reporter gene, chloramphenicol… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.