Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.

@article{Brants2004DifferentialRO,
  title={Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.},
  author={Jan R. Brants and Torik A. Y. Ayoubi and Kiran K Chada and Kathleen Marchal and Wim J. M. Van de Ven and M. R. Petit},
  journal={FEBS letters},
  year={2004},
  volume={569 1-3},
  pages={
          277-83
        }
}
The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor… CONTINUE READING
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