Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.


Estrogen has both rapid and longer term direct effects on cardiovascular tissues mediated by the two estrogen receptors, ESR1 and ESR2. Previous work identified that estrogen regulates the expression of inducible nitric oxide synthase (NOS2A) in vascular smooth muscle cells (VSMC). ESR2 knockout mice have vascular dysfunction due to dysregulation of NOS2A… (More)
DOI: 10.1677/JOE-07-0292


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