• Medicine
  • Published in
    Thyroid : official journal of…
    1998

Differential regulation of the human thyrotropin alpha-subunit promoter by thyroid hormone receptors alpha1 and beta1.

@article{McCabe1998DifferentialRO,
  title={Differential regulation of the human thyrotropin alpha-subunit promoter by thyroid hormone receptors alpha1 and beta1.},
  author={Christopher J McCabe and Nicola J. Yarwood and James A. Gurr and Neil J. L. Gittoes and Michael Charles Sheppard and Jayne A. Franklyn},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={1998},
  volume={8 7},
  pages={
          601-8
        }
}
The differential tissue expression of thyroid hormone receptor (TR) isoforms implies that they fulfil different roles in mediating triiodothyronine (T3) regulation. We have examined the differential roles of TR isoforms in mediating T3-dependent repression of the human thyrotropin (TSH)-alpha subunit gene promoter in vitro, and have assessed TR binding characteristics using gel mobility shift assays. Expression of transfected TR in JEG-3 cells revealed that TRalpha1 and TRbeta1 differentially… CONTINUE READING