Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2.

@article{GautierStein2003DifferentialRO,
  title={Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2.},
  author={Amandine Gautier-Stein and Claire Domon-Dell and Alexandre Calon and Isabelle Bady and J. -N. Freund and Gilles Mithieux and Fabienne Rajas},
  journal={Nucleic acids research},
  year={2003},
  volume={31 18},
  pages={5238-46}
}
Glucose-6-phosphatase (Glc6Pase), the last enzyme of gluconeogenesis, is only expressed in the liver, kidney and small intestine. The expression of the Glc6Pase gene exhibits marked specificities in the three tissues in various situations, but the molecular basis of the tissue specificity is not known. The presence of a consensus binding site of CDX proteins in the minimal Glc6Pase gene promoter has led us to consider the hypothesis that these intestine-specific CDX factors could be involved in… CONTINUE READING

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